Histomorphology and Molecular Profiling of Well-Differentiated Squamous Cell Carcinoma of the Esophagus Including its Unusual Variants

Esophageal verrucous squamous cell carcinoma and esophageal cuniculatum are rare variants of extremely well-differentiated carcinoma. These tumors share similar risk factors clinical presentations with conventional However, these have distinct morphological features, molecular mutation profiles, outcomes. Diagnosis can be challenging, requires high suspicion, often only diagnosed on a deep mucosal biopsy or resection specimen. Surgical treatment endoscopic curative in early disease. This review presents the histomorphology profiling type